Articles on this Page
- 06/04/18--20:33: _Contemporary Art Pr...
- 06/04/18--20:34: _Dating with Purpose...
- 06/04/18--20:39: _Altus Chiropractic ...
- 06/05/18--08:10: _Shanghai Metal Corp...
- 06/05/18--09:49: _Une nouvelle agence...
- 06/05/18--13:11: _The Cigar Virgin Co...
- 06/05/18--13:34: _Ancient Thrace Arte...
- 06/06/18--08:46: _BREAKING NEWS: Balt...
- 06/06/18--10:33: _Eye Love Sunglasses...
- 06/06/18--12:12: _AICHAIN is developi...
- 06/06/18--12:15: _WPS Office Is The B...
- 06/06/18--17:09: _La collection de tr...
- 06/07/18--08:35: _Prostate Enlargemen...
- 06/07/18--08:38: _July Suicide Preven...
- 06/07/18--10:45: _GRAB CHEAP MILITARY...
- 06/07/18--12:57: _Beat Bankruptcy Cle...
- 06/07/18--12:57: _Reinventing Modern ...
- 06/07/18--15:59: _Versara Trade – The...
- 06/07/18--17:39: _OXITOPE ANNOUNCES N...
- 06/07/18--17:41: _Shenzhen Yida Acryl...
- 06/04/18--20:33: Contemporary Art Projects USA – Participation at Art Santa Fe 2018
- 06/05/18--13:34: Ancient Thrace Artefacts Lecture About the Vasil Bojkov Collection
- 06/06/18--10:33: Eye Love Sunglasses – 5 Reasons to Wear Sunglasses All Year Round
- 06/07/18--10:45: GRAB CHEAP MILITARY SUNGLASSES ONLINE BEFORE IT RUNS OUT
Miami, FL, USA – Contemporary Art Projects USA/Gallery announces its return to ART Santa Fe at the Prime Fair Location, Booth #205; as the fair celebrates its eighteenth successful year this summer July 12-15, 2018, when galleries from around the world will once again offer an outstanding overview of modern and contemporary art. Designated as one of UNESCO’s Creative Cities, Santa Fe is a globally familiar art destination. The city claims the second largest art market in the United States and draws scores of national and international visitors. The Wall Street Journal’s Smart Money magazine recently noted: “Santa Fe is dotted with 240 art galleries, and is the home of Art Santa Fe, an international curated art fair that attracts buyers and tourists from around the world. The Santa Fe Art scene is one of the best you will find anywhere.”
According to Our Chief Curator, Mariavelia Savino: “A general language of artistic expressions has developed today regardless of diversity, contrast or innovation: similar issues are depicted around our world through the digital era. As a result, for this exhibition I look for the universal and the significant. Particularly, I will look for ART as a vehicle for uplifting Humankind, for love and understanding, for creativity and uniqueness, for highlighting Nature, the beautiful and the positive.”
To define this year’s Contemporary Art Projects USA booth at Art Santa Fe 2018, the group of artists presented are national and international from the Americas, Europe and Asia. From very Figurative to Abstract, as well as Geometric and Kinetic. Their artworks represent all media, from sculptures to photography, painting, tridimensional collages, some made on precious mixed media, metal or Plexiglas. In our booth, we made real the term “Allure“, which is the leading motive of this Art Fair, the undeniable power of Contemporary and Modern Art to captivate, seduce, and charm buyers, collectors, and dealers who love their work. At the same time highlighting the unique creative message of each artist, everyone so different from the other, but forming a whole to celebrate through their talent: humanity, beauty, nature and life.
We are honored to present the extraordinary art by Rim Chae, Invited International Artist/Asia, Ricardo Cardenas and Ricardo Lowenberg, Invited International Artists/Mexico, Kelly Fischer, Invited International Artist/Europe, Miguel Paredes, Guest Artist/USA and a relevant group of emerging artists that will be a highlight of the exhibition.
So, join us this summer for Art Santa Fe 2018 alongside an illustrious line-up of art lovers and high-net-worth collectors with average household incomes of $200,000+!!!!!!
Opening Night Preview Party
Thursday, July 12, 2018 | 5 p.m. – 9 p.m.
Open Show Days
Friday, July 13, 2018 | 11 a.m. – 7 p.m.
Saturday, July 14, 2018 | 11 a.m. – 7 p.m.
Sunday, July 15, 2018 | 11 a.m. – 7 p.m.
Santa Fe Convention Center
201 W Marcy Street
Santa Fe, NM 87501
Total Ticket Pass: $100 (Admit 2 people)
General Public: One-day pass $20
Three-day pass $25
Student/Senior: One-day pass $10
Three-day pass $15
About Contemporary Art Projects USA
Headquartered in Miami, Contemporary Art Projects USA (http://www.contemporaryartprojectsusa.com), is dedicated to nurturing new contemporary art by providing exhibition opportunities and resources for emerging artists and curators. Their mission is focused on promoting art appreciation within the international community, to inspire and assist with the process of the art collection, and to generate resources that support artists’ creative endeavors through art awareness, artist promotion, and art procurement.
They work with the best minds in the industry and share their experience and passion for marketing the arts, culture, and entertainment. From Biennials and gala auctions to exhibitions and major international art fairs, Contemporary Art Projects USA has the experience, innovation, and creativity to engage audiences through inspired campaigns.
Company Name: Contemporary Art Projects USA
Contact Person: Tata Fernandez, Director
Email: Send Email
Country: United States
Dating has become an escape for those afraid of commitment, at the expense of sincere hearts searching for true love. Yet dating that was designed by God has the prerequisite that it is headed toward a Godly union in the constitution called “marriage.” Dating with Purpose is a life-changing book written by Aldi Essandjo. A prolific and edifying preacher, speaker and author.
Dating with Purpose will uncover the desires that lead to unfaithfulness to God for the sake of being faithful to your significant other. Also, it uncovers the danger of memories, the pressure to heal and the pressure of marital benefits.
Purchase “Dating with Purpose” today at http://www.ucgglobal.org and learn how exposure decreases your love for your spouse and men’s habit of keeping their options open while making you feel special, and much more!
“Dating with Purpose: Why You Shouldn’t Date Unless You Intend to Marry” deals with the unseen and spiritual aspects of dating that the human eye overlooks. Dating without the intention of a godly marriage results in the relationship embracing the benefits of marriage and the spiritual ramifications associated with those “benefits” outside of God’s will and timing.
When we asked Aldi Essandjo about his intent for writing Dating without Purpose, He answered humbly stating “God gave me this book during my hours of counseling many men and women, single and married. The spiritual and emotional pains they encountered throughout their dating process caused me to run to God for answers. Thankfully, He answered!”
Purchase “Dating with Purpose” and get your copy today at http://www.ucgglobal.org.
Abbotsford, BC – Altus Chiropractic and Physiotherapy based in Abbotsford BC, are delighted to announce that they have recently received a 5-star review from a patient who was delighted with the results of their treatment. The company specializes in the treatment of neck and back problems, sports injuries, and the reduction of pain. This is one of many satisfied customers; as can be seen by reading the reviews about Altus Chiropractic and Physiotherapy on Google Maps.
All of the staff employed in Altus Chiropractic and Physiotherapy are passionate about delivering the best treatment possible for their clients. They keep up to date with the latest developments in the world of chiropractic care and physiotherapy treatments, and regularly attend conferences to ensure that they are at the forefront of any medical breakthroughs. They are particularly proud of this Abbotsford Physiotherapy Client Testimonial Video, as they feel that it validates the extra effort and dedication they put into every patient.
“Sometimes, I feel like I have the best job in the world,” said Dr. Trang Luu of Altus Chiropractic and Physiotherapy. “Every hour of my working day is spent actively helping other people to improve the quality of their lives. When a client takes the time and effort to visit a website and write such a glowing review, you know that you have had a huge and positive impact on their life. I wish there were more hours in the day so we could help even more people.”
ALTUS Chiropractic and Physiotherapy is an Abbotsford BC clinic with professional chiropractors and physiotherapists who specialize in sports physio or helping clients restore their health & wellness. ALTUS continually receives 5-star reviews & ratings from its clients, who have noticed a significant improvement in their health and mobility. For more information about the company, or to book a treatment session, visit their website at https://www.altuschiroandphysio.com/.
Company Name: ALTUS Chiropractic and Physiotherapy
Contact Person: Dr Trang Luu
Email: Send Email
Phone: (604) 853-3212
Address:32920 Ventura Avenue
With the objective of providing support to both local and overseas industries who continually strive to reduce production cost and meet up with deadlines, Shanghai Metal Corporationannounces its advanced metal fabrication technology, products such as the Hastelloy C276, Hastelloy B, Hastelloy C22 and other affordable engineering services. The company ensures an increased production of other steel alloys, construction services as well as other metal works at very low costs.
Metal fabrication and manufacturing has evolved over the years due to the changing market demands. Today, SMC introduces the new technology of bending, cutting and assembling of huge quantities of metal parts for numerous forms of applications. As part of their many products, the company specializes in the manufacture of steel alloys one of which is the Hastelloy C-276. This unique alloy is known for its ability to resist grain boundary precipitates formation in weld heat-affected parts which makes it more sustainable for industrial applications such as in flue gas desulfurization systems. This unique steel alloy is made available by the company due to their excellent resistance to a wide variety of chemical process and their subsequent reactive effects.
Also available is the Hastelloy B which is a nickel-molybdenum alloy specifically suited to handling harsh temperatures as well as high concentrations of acids. This alloy has been applied in the production of acetic acid, insecticides, herbicides, ethylbenzene and ethylene glycol. This product has also found application in the production of high-octane gasoline and more.
SMC has a team of engineers who are experts in the manufacture of Hastelloy C-22, a nickel-chromium-molybdenum-tungsten alloy. This metal product also shows high resistance to stress-corrosion cracking, pitting, and crevice corrosion. This product has also been made available to customers due to its suitability for most chemical process applications. Clients who are interested in knowing more about Shanghai Metal Corporation, their products, and other services can visit their website on www.shanghaimetal.com
About Shanghai Metal Corporation
Shanghai Metal Corporation, a Chinese giant manufacturing company with over 3 years of experience, specializes in the manufacture of Metal products, Electric system, Machinery and parts, and Construction equipment. Their products include high-quality aluminum, stainless steel, copper, carbon steel, galvanized steel and other steel structures as applied in coils, strips, foils, pipes, sheets, bars, fittings and more. The company also engages in the supply of these products, in addition, other services.
ConceptionWeb360, nouvelle agence web de conception de sites internet, ouvre ses portes dans la ville de Quebec. Quels que soient vos besoins de marketing en ligne ou de referencement web, cette agence québécoise offre maintenant des conseils en marketing directement avec des professionnels!
Agence de marketing Internet
Avec des demandes toujours croissantes au sein de l’univers en ligne, l’agence Web ConceptionWeb360 est destinée à la création de sites web à Québec. Elle prend soin de vos besoins de A-Z – allant du marketing au référencement, et tout ce qu’il y a entre les deux!
Non seulement cette agence de marketing Internet saura combler vos attentes, mais son objectif principal est de rendre votre site Web entièrement fonctionnel, facile à utiliser, attrayant et unique, vous laissant 100% satisfait. De plus, votre site internet sera totalement réactif, ce qui signifie que le contenu conviendra à toutes les plateformes: ordinateur, téléphone mobile et tablette. ConceptionWeb360 est une agence tout-en-un où vous pouvez avoir la tranquillité d’esprit en sachant que votre site internet sera non seulement de haute qualité, mais également à la fine pointe de la technologie.
De nos jours, disposer d’un site internet est pratiquement obligatoire mais plus important encore, votre page doit se trouver parmi le réseau web mondial! C’est ici qu’intervient le référencement web, également connu sous le nom de SEO – l’optimisation de la performance de votre site internet afin d’atteindre un meilleur classement sur de nombreux moteurs de recherche tels que Google, Yahoo ou Bing. ConceptionWeb360 dispose d’une équipe d’experts connaissant les bonnes stratégies pour optimiser les performances de votre site et donc la visibilité et le trafic.
Visitez http://conception-site-web-quebec.business.site dès aujourd’hui pour prendre votre premier rendez-vous!
Conception Web 360 | Création Site Web et Référencement Web Québec
1533 Rue Auguste Comte
Québec, QC G2E 4G9
Un guichet unique pour tous vos besoins de référencement web
La création de sites Web à Québec n’augmente pas seulement en popularité, mais également en demande.
En effet, l’expertise et l’expérience de ConceptionWeb360 ne se limitent pas à la création de sites internet. Cette agence de marketing web va bien au-delà de la simple conception: il s’agit d’une agence unique et entièrement nouvelle au Québec qui peut prendre en charge vos stratégies internet, votre marketing web et même votre référencement Google. À la fois professionnel et efficace, ConceptionWeb360 vous offre tous les services dont vous avez besoin pour vous démarquer dans l’univers en ligne.
Les professionnels chevronnés de ConceptionWeb360 vous accompagneront étape par étape et vous conseilleront correctement dans votre projet. Si vous êtes prêt à faire le premier pas vers une collaboration en toute confiance avec une agence de pointe, que ce soit pour le marketing en ligne, la création de sites internet ou même pour revoir complètement votre site existant, ConceptionWeb360.ca est l’équipe que vous cherchez. En établissant dès le départ une analyse stratégique orientée vers vos objectifs d’affaires et sur mesure pour votre clientèle, préparez-vous à la réussite en ligne dans un proche avenir!
L’article a été publié en premier ici: Une nouvelle agence de conception de sites web et référencement web à Québec.
Company Name: Jonathan Loiselle Media
Contact Person: Jonathan Loiselle
Email: Send Email
Phone: (418) 473-1544
Address:2388 Avenue de Lisieux
City: Ville de Quebec
State: QC G1E 0E9
The Cigar Virgin is a site dedicated to providing information to people who are both new and experienced in smoking cigars. The site contains a good introduction on cigar quality, how to define the perfect cigar, and whether it is a healthier alternative to cigarettes. The Cigar Virgin also contains a range of reviews of the best accessories including cigar cases, ashtrays, cutters, and humidors.
What makes The Cigar Virgin stand out from other websites is its comprehensive introduction to cigars for the novice smoker. This comes in the form of three main articles. The first one discusses the quality of the cigar and gives an overview of the rights and rituals around smoking a cigar, and the different variety of sizes, flavors, and shapes available. The article also lists the countries where cigars are manufactured and the three vital components to a quality cigar: wrapper; binder; and, tobacco.
The second article talks about the definition of a good cigar, which although will vary from person to person is distinguished by a series of factors. The factors mentioned include the size of the cigar, which will affect the flavor; the body of the cigar, which is categorized as full-bodied, medium, or mild flavoured, and ratings, which range from 0 to 100 and has been developed by Cigar Aficionado magazine. How a cigar is rated is affected by a range of factors including flavor, aroma, construction, appearance, how it smokes, and the balance of competing aromas.
The Cigar Virgin’s third main article discusses whether cigars are a healthier alternative taking care to highlight the importance of moderation. The article briefly mentions studies that investigate the positive effects of nicotine and then moves on to list the benefits. These include: increased motivation, creativity, and alertness; helps with stomach problems; anti-inflammatory properties; provides pain relief; improves fine motor skills, memory, and attention; helps schizophrenia sufferers; helps control weight and insulin; and, helps repair tissue damage.
In addition, The Cigar Virgin provides a series of reviews and buying guides on cigar ashtrays, cutters, cases, and humidors. These reviews contain information on their price along with links to Amazon, and their main features such as size, design, and the materials they are made from.
Interested readers can find out more at www.thecigarvirgin.com
Company Name: The Cigar Virgin
Contact Person: Gary Lodge
Email: Send Email
Address:656 Joy Lane
City: Los Angeles
State: CA 90017
Country: United States
On the 3rd of May 2018 Prof. Dr. Athanasios Sideris, Head Curator of the Vassil Bojkov Collection, presented an hour and a half public lecture as a special event in the exhibition “The Golden Fleece. The Quest of the Argonauts” – Vassil Bojkov Collection.
The lecture Legends on Silver. From Athens and Ionia to Thrace and Scythia was held at the National Gallery – The Palace, Sofia and hosted more than 150 attendants.
During the lecture, Prof. Sideris discussed a large number of rare and exceptional silverware artefacts from the Early Archaic to the Late Hellenistic periods from the territories of Ionia and Athens to Thrace and Scythia.
Most of the discussed antique vessels and utensils were once part of the drinking sets used during symposiums and banquets. Such drinking parties, firstly introduced from The East and lately adopted by the Greeks, are said to have been accessible only to the uppermost levels of society and naturally, the precious vessels used for the occasions were of exceptionally high quality craftsmanship.
The silver vessels were often decorated with mythological, epic or religious scenes. In his lecture, Prof. Sideris explained how such scenes were usually adapted to local traditions and rituals or were sometimes even used as political propaganda. A witness of such practice is a silver kylix with Theseus and the Marathon bull dated to the 445-440 BC, now part of the Vasil Bojkov Collection. The gold leaf decoration inside the silver drinking cup shows Theseus taming the Marathon bull.
According to various ancient sources, the young Athenian hero went to Marathon, captured the mad bull using his club and led it through Attica to the Acropolis, where he sacrificed it to the goddess Athena.
After the Persian wars, there was in Athens a conscious political effort to promote Theseus to the rank of a national hero. To this effect, sometime in the late 70s or early 60s of the 5th c BC, the general Kimon brought from the island of Skyros ‘the bones of Theseus’, buried them in Athens, erected a shrine dedicated to the mythological hero and reinvigorated a pre-existing cult.
Theseus himself, his life and his labours became thus a symbolic expression of the Athenian achievements during the Persian wars. What could be a more eloquent praise of the Marathon battle than the commemoration of the capture of the terribly destructive animal by Theseus in the same plain?
In his lecture, Prof. Sideris also presented the ways of acquisition and circulation of these luxury items, of which the largest and most representative assemblage belong to the collection of Vasil Bojkov.
The artefacts discussed in the lecture are issued from diverse cultural and stylistic traditions. They have been produced in various workshops all over the ancient art world and many of them were lately brought by Athenian delegations as diplomatic gifts to the local Thracian tribal chiefs in order to obtain access to goods such as precious metals, timber and animal furs. But most of these artefacts arrived by trade and they even have been used as a form of payment. Finally, other ways of acquisition were not excluded, such as war booty.
Baltimore, MD, USA – Dr. Keenan Cofield, the Baltimore, MD Supreme Grand Bishop may own your domain name. Bishop Dr. Cofield, owns more than 600 plus domain names, .dot apps and .coms between GoDaddy and 2 other companies. Photo link of Dr. Keenan Cofield, the Baltimore Supreme GRAND Bishop.
Dr. Keenan Cofield, the Baltimore Supreme “GRAND” Bishop is the largest (Black) and minority owner of domain names in the world.
Recently, Google paid 25 Million dollars for the .apps domains registry. Two weeks ago, .apps was made available for the first time to everyone in the world. Originally, only developers and other domain BIG name insiders like early shareholders for stock had any right to bid as part of the pre-registration process until now, at the direction of Google.
“I have only released half of my domain name properties listing to the public for viewing,” Bishop Cofield said. Dr. Cofield states his .coms and .apps are some of the world’s most powerful names, like the Queen, Pope Frances, United Nations, Award Shows, Hospitals, AP Associated Press, New York Stock Exchange, Facebook, Google, Fed Exp, Am Exp., television programs, newspapers, radio/tv stations, Saudi Royal family members, billionaires, wealthy families, cities and states, government officials, locations, companies, to quotes, to just name a few to his portfolio listings. Bishop Dr. Keenan Cofield had his domains portfolio appraised that exceeded millions of dollars $$$$, for many domains in his custody. The minimum of Dr. Cofield’s .coms or .apps is $500 dollars up.
President Donald Trump’s, his companies, properties, names, along with his son-in-law New York businesses have gotten the most calls or emails, to the tune of over 200. Everyone wants a piece of this! Out of respect for the President and his family business, President Trump has first shot to acquire every domain I own in his family business names. Everyone I talked to by phone or email wants to pay BIG money to keep President Trump’s hands off of his many domains I own. “I have two business matters with the President, that “does not” include money.”
The United States government came in second of hot domains people wanted to buy from me. There is nothing like owning a piece of power, wealth and influence in the United States of America and Worldwide. This is better than any real estate deal!
Listen, all companies want to have an application version of their site properties on the internet so customers, clients and others have direct access and use of their smartphones and tablets. When anyone has your .app or even dot com, there are many risks associated with someone owning your domain name or names in any combination or variation thereof. Clearly, this is all about business…
Recently, AIG insurance contacted me by email wanted their domain name they did not protect nor register, my counteroffer was $5,000,000 for aiginsurance.app, a much valuable worldwide company.
Attached is a short list of my edited list of domain name offerings I have to sale or trade for something, and The Supreme GRAND Bishops YouTube Video link on this subject: https://i.ytimg.com/an_webp/BgZVPJAnaLs/mqdefault_6s.webp?du=3000&sqp=CITG2tgF&rs=AOn4CLAd6I83M5pUY9fxB_z1SJDq_tSlBA.
EDITED SHORT LIST OF MY OWNED DOMAIN NAMES
Company Name: Office of the Supreme GRAND Bishop
Contact Person: Dr. Keenan Cofield, The Supreme GRAND Bishop
Email: Send Email
Country: United States
United States – Sunglasses may be cool and trendy. But these important pairs of eyewear provide much-needed protection and should not only be worn on the beach during summer but all year round. Here are just a few benefits:
1. Sunglasses protect your eyes from the sun’s ultraviolet rays. Prolonged exposure to the sun may lead to eye health problems such as cataracts, pinguecula, pterygia, and macular degeneration. When purchasing sunglasses, look for ones that block out 99 to 100% of both UVA and UVB radiation, so you can keep your vision sharp and eyes healthy. Check out Eye Love brown tortoise and gold sunglasses for full UV protection.
2. Windy environments and dry climates may increase the suffering of people who have dry eye syndrome. Sunglasses can keep your eyes safe from the wind, dust, and other debris entering your eyes. A wrap-around style of sunglasses can help prevent you from experiencing the symptoms of dry eye syndrome.
3. Sunglasses reduce glare while engaging in outdoor activities like driving, fishing, and boating. The bright sunshine through your windshield can be blinding, and it may increase the risk of you getting into an accident. Wearing sunglasses may not only help you feel comfortable, but it can also increase safety for you and your passengers. Eye Love’s classic black Wanderers come in matte or shiny options and are great for any occasion.
4. Sunglasses can advance healing and recovery if you have had surgical procedures to correct your vision. Your eyes will be more light sensitive at first, so ask your doctor for opinions and recommendations for a pair of sunglasses after the procedure. You may want to continue wearing them to protect your eye as it heals and as you adjust to your newly restored vision.
5. Sunglasses reduce squinting and eye strain. Wearing them will allow you to see things more clearly and will help your eyes feel less tired. Constant squinting can cause premature crow’s feet at an early age. There may be many products that help reduce wrinkles, but why waste money on them when a proper pair of sunglasses does the trick? If eye health is not your concern, perhaps looking younger longer will encourage you to wear a pair!
Sunglasses may come in different shapes, colors, and styles and they may add glamour to your daily outfit. But these accessories are far more than just a fashion addition. They’re a must have to help protect your eyes during daily outdoor activities.
Check out the Eye Love Best Sellers on Amazon and get your favorite pair. All Eye Love sunglasses are polarized with 100% UV blocking and glare free lenses. With every product purchase, Eye Love gives an eye exam, glasses and sunglasses to someone in need for their Buy One, Give One mission.
EOS, in which the famous internet security enterprise 360 found a series of high-risk security vulnerabilities existed some time ago, announced earlier today that one alternative main net had been generated after the efforts of eastern and western communities.
Regardless of any security vulnerabilities, EOS continues pushing online operation of main net with efforts, and further verify the significance of main net from the side.
2008 is an important year for the contest of public chain, and Ethereum, EOS, NEO and Qtum of China are trying all ways to compete with each other. After all,main net will become the bottom-layer operation system of block chain in the future, and the one that grasps main net will grasp the operation system and get the profits in the future.
However, from wide view of the current main net, its main directions of application are Bitcoin, Ethereum, HyperLedger, a majority of competitive currencies, etc., the advantages of main net lie in anyone can easily enter only with one internet-connected computer.
After entering main net, the block chain’s underlying architecture and digital resource dissemination protocol can be built to support third-party developer to build its own application under the open source license and jointly form complete ecology of block chain technology and application with many industry partners.
Meanwhile, third-party developer can also issue token to build its own economic system, develop various applications with focus on the main net of each block chain project sponsor, and utilize token in the public block chain as the certificate in the system.
Therefore, it is understandable that main net is called as the a hotly contested spot.
As one block chain + AI project sponsor, AICHAIN is developing the online work related tomain net in full swing, and relevant information also disclosed that AICHAIN is likely to enable the online operation ofmain net 2 – 3 months in advance compared with the date planned in white paper.
Upon the online operation of main net by AICHAIN, it will be open totally to the public without limitation, DAE platform built by AICHAIN based on the main net will ensure that all resource contributors and users can carry out the digital information transmission and transaction related to block chain.
Whether you are a student, professional, or small business owner, you need quality office software. Surprisingly, some of the best office suites are completely free and available on the most popular operating systems.
New Windows 10 PCs are preloaded with a trial of Microsoft Office, but after expiration, you will need to find an alternative. Macs are equipped with Apple’s own office suite, but you might need a cross-platform suite to work with PC users.
So what is the best free office suite on the market? Factors to consider are price, operating environment, delivery method and extra tools and services. You need to weigh each criterion against your needs to select the software that’s best for you.
LibreOffice is a good option to start in your search for a good Office application. It’s compatible with all Microsoft document formats, and has most features in the latest versions of Word, PowerPoint and Excel.
The suite contains six programs to cover every common office task: Writer, Calc, Impress, Draw, Math and Base. The last three are tools designed for vector diagrams, math functions and databases. The latter is particularly useful if you work with large amounts of data.
LibreOffice is an open source project maintained by a large community of volunteers constantly working to improve stability and add new features. There’s a vast array of extensions and templates to make it even more flexible, and it’s free for businesses as well as personal users.
LibreOffice is available for Windows, Mac and Linux, but the main drawback is there are no mobile versions available except for a document viewer for Android.
Google Docs, Sheets, and Slides
If you work collaboratively, or switch between a PC and a Mac, Google Docs, Sheets and Slides should be considered.
For people who are already familiar with the Android and Google ecosystem, this suite will be a natural choice. The three key tools run well in any web browser, and are available as mobile apps for iOS and Android devices.
Google’s free office suite is limited in functionality. It doesn’t offer the advanced tools you’ll find in desktop software like WPS Office (for example there are no pivot tables or shareplay option in presentation) but everything is displayed in a clear manner. All your files will be saved and synced automatically so you don’t have to worry about transfers and backups.
The chief disadvantage of Docs, Sheets and Slides is that opening files created using other office software is a troublesome process and files aren’t converted correctly often.
This is partly because Google’s office tools use web fonts rather than ones stored on your local device, and also because Microsoft documents sometimes contain features not supported by Google.
If file compatibility is a must have for you in your daily use, move on to the options below.
Microsoft’s desktop software requires a subscription fee, but the firm has created its own set of free online apps to combat the other free offerings.
Microsoft Office Online looks and works just like its desktop equivalent, and although advanced tools like pivot tables are lacking, it is on par with Google Suite.
If you generally use Microsoft document formats, Office Online is a common choice. Unlike Google’s apps, it doesn’t need to convert your files before you can work on them, and you can share them easily through your OneDrive account. Use your Microsoft account to access cloud services and you’re all set.
There’s a version of Office Online for Chrome, plus mobile editions of Office for iOS and Android.
WPS Office Free is a smaller version of a premium office suite, but you will find its power is good for most of your needs. Each of its three programs looks comparable to the latest versions of Word, Excel and PowerPoint, and is loaded with just as many features.
File format support is excellent, and you can save your work in native Microsoft formats for easy sharing with Office users. WPS Office comes with an excellent free PDF reader that’s a great for reading contracts and other secure files.
To offset the costs of offering the features, these are a few ads. They won’t block your work, and you’ll be amazed that everything in this suite is completely free.
WPS Office Free is available for Windows and Linux systems, as well as apps for Android and iOS devices.
In conclusion, after considering the best file compatibility with Office, rich feature set, and price, the best choice for an Office suite is WPS Office.
About WPS Office Software
Palo Alto-based WPS Office is a leading provider of office software for PC, mobile, and cloud users. With more than 1.2 billion installs, WPS Office is a high performing, yet considerably more affordable office software solution that is recognized as a preferred alternative to Microsoft® Office and fully compatible and comparable to Microsoft Word, PowerPoint and Excel. The WPS Office software suite is available for Windows and Linux-based PCs as well as Android and iOS. WPS Office Software is a subsidiary of Kingsoft Corporation, China’s leading Internet services and software company.
More information can be found at https://www.wps.com
Follow us on Twitter @WPS_Office and Facebook (https://www.facebook.com/kingsoftwps)
Imaginez que vous êtes un noble dans la Grèce antique. Vous commandez un objet exquis pour orner votre maison, qui attirera l’attention de vos invitées. Vous devenez si attaché à l’objet magique, qui se trouve être un kantharos d’argent représentant une scène de sacrifice, que vous sentez que vous ne pouvez pas vivre sans lui. Littéralement. Quand vous mourez, vous êtes enterré avec votre possession la plus glorieuse. Le kantharos à tête de lion, avec beaucoup d’autres pièces d’or et d’argent, sera avec vous lorsque vous rencontrerez la myriade de dieux et de déesses grecques. Il sera avec vous pendant 2400 ans, jusqu’au jour où il sera découvert par un archéologue très chanceux.
Les admirateurs de l’art ancien sont présentés avec une occasion rare d’admirer cette pièce unique, ainsi que de nombreux autres beaux objets. L’un des hommes les plus riches d’Europe, qui est aussi un collectionneur avide, a décidé d’exposer soixante deux objets de sa collection personnelle, dont dix sept sont présentés pour la première fois. Les objets emmènent le visiteur dans un voyage magique à travers la Grèce antique. L’incroyable collection du Le célèbre homme d’affaires et philanthrope Vasil Bojkov est présentée dans un catalogue de collection spécial, qui peut être acheté sur amazon.com ou du site Web de la Collection Vasil Bojkov. Ici, le lecteur peut trouver des détails sur 146 objets en mettant l’accent sur les vases et les ustensiles en métal.
L’auteur, Dr. Athanasios Sideris est un archéologue classique avec une solide expérience en histoire aussi qu’en histoire de l’art. Il a étudié à l’Université Charles (Prague), à l’Université Denis Diderot (Paris 7) et à l’Université de Bourgogne (Dijon) avec Jan Bouzek, Pierre Vidal Naquet et Claude Rolley. Il est consultant scientifique de l’Université de la mer Égée (Rhodes), Il dirige les fouilles et les levés archéologiques dans la région de Kastrouli, Phokis, en collaboration avec l’Université de Californie à San Diego. En avril 2011, il a dirigé les recherches sur le champ de bataille de Gaugamela, dans le nord de l’Irak. Depuis 2009, il co-dirige les fouilles à Halka Bunar, en Bulgarie, en collaboration avec Milena Tonkova de NAIM-BAS. De 1998 à 2013, il a été directeur du Département d’Histoire et d’Archéologie à la Fondation du Monde Hellénique d’Athènes. Comme l’exprime le travail du Dr Sideris, l’objectif du collectionneur, M. Bojkov est de rendre sa collection d’objets d’importance mondiale en permanence physiquement accessible à tous.
Benign prostatic enlargement (BPE) and chronic prostate/chronic prostatitis / chronic pelvic pain (CP/CPPS) can be treated effectively with innovative Thermobalancing Therapy and Dr Allen’s Device. Since the device treats the prostate itself, but not the symptoms, it should be used in the first instance.
The side effects of most common drugs for the prostate treatment can develop tiredness and fatigue, sexual problems, such as decreased sexual interest and ability, impotence, testicle pain or swelling, and even diabetes. Medications are unable to treat prostate enlargement and inflamed prostate, therefore, different surgical interventions are widely used. At the same time, any operation involves removing or destroying part of the prostate or the whole prostate that usually leads to irreversible health problems.
Dr Allen’s device relieves urinary symptoms in men with BPE, also called benign prostatic hyperplasia (BPH). The symptoms, such as frequent or urgent need to urinate; increased frequency of urination at night; difficulty with starting urination; weak urine stream, etc, can also disturb men with CP/CPPS. The unique device provides chronic pelvic pain relief, improves potency and well-being in men with BPE and CP/CPPS. Please watch videos: https://youtu.be/n4ZWUZGhyxo and https://youtu.be/Fr3oFP8p3ks.
2 clinical studies has demonstrated that Thermobalancing therapy enabled by Dr Allen’s device reduces the size of enlarged or inflamed prostate. Indeed, this is the reason of the improvement in the BPH or CP/CPPS symptoms. The outcomes of the clinical trial have been published in different leading medical journals of the British and Iranian Urological Associations, in a leading journal of older men, Aging Men Journal, and in many others, and have been discussed at various international conferences across the globe, including in London, Spain, China, Italy.
“Men should stay away from prostate drugs or surgeries, as they are last resort treatment options. The device I have invented is effective as it treats the cause of non-malignant prostatic diseases, by improving blood circulation inside a prostate,” comments Dr. Simon Allen. “Therefore, the device should be used as the first-line treatment for benign prostatic hyperplasia and chronic prostatitis.”
Fine Treatment delivers the device for prostate treatment and to all countries across the world. Fine Treatment is a UK Department for International Trade (DIT) registered supplier to international buyers: https://trade.great.gov.uk/suppliers/08994517/fine-treatment-limited.
Dr Allen’s Device is a Class I Medical Device, which does not require the involvement of a Notified Body at any country. So, everyone can use it at home without worrying, as this treatment option causes no side effects. Men can receive the device within a week, and use it at home. For over 10 years Dr. Allen’s Devices have been delivered for thousands of customers via Royal mail tracking service. Today, the devices have been successfully used by customers in over 100 countries. Read more at: https://finetreatment.com.
Company Name: Fine Treatment
Contact Person: Dr Simon Allen, MD, PhD, Director of Fine Treatment
Email: Send Email
Country: United Kingdom
Los Angeles, CA, USA – Professional Psych Seminars, an online mental health continuing education website, announced today that Dr. Susan Marie, PMHNP, and Ph.D., will host the “Suicide Prevention: New Interventions That Work” seminar on July 21st in West Los Angeles at the West LA Luxe Hotel. This course will outline zero suicide approaches, the confidence that suicide deaths in health and behavioral health systems are avoidable. Seminar students will learn up-to-date information regarding suicide assessment, intervention, and prevention of particularly the high-risk veteran, elderly, LGBTQ, and teen populations.
As a Clinical Associate Professor at Oregon Health & Science University, specializing in psychopharmacology for complex patients and psychopharmacology consultation to other professionals, Dr. Marie has over 30 years of experience training professionals in suicide assessment and intervention. Students will learn the six steps of a suicide safety plan, explore critical factors in suicide risk assessment and interventions amongst veteran populations and other high-risk groups, expand current evidence-based knowledge of prevention, and learn how to define the nature of crisis to increase the effectiveness of an intervention. This seminar meets the updated requirements for Suicide Prevention Training, per Assembly Bill 89 (AB 89), for California psychologists, effective January 1st, 2020.
“Suicide kills twice as many people in California as homicide, but not all mental health care providers have the training they need in suicide risk assessment and prevention,” said Assembly Member Levine, at the AB 89’s signing in September 2017. To combat this deficiency, AB 89 requires “individuals applying for licensure as a California psychologist to complete a minimum of six hours of coursework or applied experience in suicide risk assessment and intervention”. Authored by Levine, “AB 89 will save lives by making sure psychologists have the training they need to care for their patients.”
Professional Psych Seminars is an online mental health education platform for continuing education for psychologists, mental health professionals, and social workers. Mental health professionals have access to the latest research and innovation education through online and live, in-person classes to maintain and update their personal and professional knowledge and certifications. With continued access to classes, practitioners can effectively serve their clients that meet state licensing requirements in theory, research, and practice.
For the men and women in service and in harm’s way, wearing ballistic military sunglasses is one of the safest ways to protect their eyes.
It’s not just the protection of the eyes from the very bright sun that shines in the lands of the Middle East and the battlegrounds, the main purpose of ballistic military sunglasses is to protect the eyes from projectiles that come from explosions, shrapnel, and splinters that comes from both bullets and explosives during their operations in the battlefield.
Before sunglasses is just an option for military personnel who are deployed in the frontlines but due to the increasing number of soldiers going blind due to shrapnel, splinters and projectile injuries sustained in their eyes which results to blindness, the government imposes a stricter rule to require each person in the battlefield to wear protective sunglasses which are usually ballistic proof aside from protecting the eyes from the harmful effects of ultraviolet rays and eventually became an essential equipment of the modern day warriors.
It’s not about wearing it to make them look cooler, they already look cool with their full battle gear on. Military men wear protective ballistic sunglasses to save their vision from the hazards they encounter in the battlefield including Improvised Explosive Devices (IED) which is the number one cause of casualties in the U.S military campaigns in the Middle East, particularly in Afghanistan and Iraq.
Unlike conventional lenses which only blocks the harmful rays of the sun and its polarized technology letting you see clearer in your surroundings, one of the United States’ main supplier of ballistic sunglasses, Oakley creates a more innovative and advanced ballistic sunglasses which is more detailed, defined and advanced compared to other brands that manufactures military sunglasses.
Oakley’s innovative technology in its military sunglasses is mainly focused on focus, clarity, and protection.
• Oakley uses High Definition Optics (HDO) which it developed to help optimize the performance and safety requirements for the military personnel wearing it. HDO is also available for Oakley’s sports performance sunglasses which offers a clearer vision and has surpassed the ratings of the American National Standards Institute (ANSI) when it comes to the clarity test it underwent.
• Oakley also uses glare protection to prevent clarity from being compromised. Patrolling under the sun can be very tough, it can give any person who undergoes this kind of task health hazards, but Oakley developed a High Definition polarized lenses to keep the eyes safe from the UV rays of the sun aside from protecting it from projectiles, shrapnel and splinters if they figured in a gun battle in their area of operation.
• Oakley also developed its Naked EyeHD polarized lenses to provide that gives the wearer a clearer vision of his/her surroundings.
CHEAPER OAKLEY MILITARY SUNGLASSES FOR SALE
As we all know, there are no cheap Oakley military sunglasses but good news, Ray-Ban, Rayban-Oakley-Sunglasses-sale.com, an online shopping website sells cheap Oakley sunglasses including Oakley military sunglasses for just $19.99 compared to the usual original price of $143.00 with the same level of quality just like what you can buy in an Oakley outlet and durability despite being a knockoff.
This website offers a year-round Oakley sunglasses sale including high-quality Ray-Ban sunglasses.
Just like any other online shopping websites, Rayban-Oakley-Sunglasses-sale.com provides its customers a very convenient payment method through credit card and debit card transactions. They accept major credit cards such as Visa, MasterCard, andAmerican Express that is available for the worldwide transaction.
Its payment transaction is completely secure and safe as well as a very convenient. Its current payment method is well secured with a data encryption technology which protects the personal information and the account information of the credit card provided by the customer. The website also uses Secure Sockets Layer (SSL) encryption technology which prevents interception of the data which is transmitted to the customer and website’s payment system.
Aside from military glasses, there are also cheap Oakley sunglasses for lifestyle and sports available year-round.
In terms of shipping and delivery, just like other online shopping sites, after purchasing the product, it will automatically have shipped within 48 hours and takes three to four business days before arriving right at your doorstep. The website also provides the customer a tracking number that will be sent through email which also includes the status of the order, the website also includes the contact information that is sent to the customer in the duration of the product’s shipping days. For offshore customers, the website requires them to purchase products over $59-dollars to avail of its free shipping fee.
Company Name: Rayban Oakley Sunglasses Sale
Contact Person: Mark C Basil
Email: Send Email
Address:2136 Progress Way, Iowa City
Country: United States
Little Rock, Arkansas, USA – Overwhelming debt can be incredibly destructive to a person or company, often resulting in the person filing for bankruptcy. Renowned California lawyer and author Greg Fitzgerald’s new bestseller, The Bankruptcy Alternative: Keys to Successful Debt Settlement, shares an insider’s view on successfully resolving debt without going bankrupt. Throughout his commendable career as a debt protection lawyer, he has worked with thousands of clients and secured many victories. In addition to bona fide strategies for debt elimination, he also shares his personal journey with debt and how he overcame it by using techniques learned over several years of personal experience and in his law practice.
The Bankruptcy Alternative is a breakthrough resource that helps readers understand how debt settlement really works. Fitzgerald goes to the very root of the problem to define the different types of debts. Along with addressing the immense power of corporations, banks and debt collection agencies that won’t stop calling, he presents an effective debt settlement approach that individuals and organizations can use to start eliminating their debts, without having to file for bankruptcy. In the past, Fitzgerald has successfully settled his personal debt of over $300,000 by using the strategies he now shares in this book.
Greg Fitzgerald boasts a commendable law career, with many achievements and accolades to his name. Having graduated from the Southern California College of Law in 1990, he passed the California bar exam and initiated his law career in 1991. During his extensive 27-year-long career, he has battled many renowned Collection law firms since founding his initial law firm in 1992. Having curated and led teams of lawyers on a national scale, he currently practices law at self-owned Fitzgerald & Campbell, a leading California law firm focusing primarily on consumer debt protection laws including student loans, collection harassment, credit card debt, business debt and much more.
Having settled hundreds of thousands of accounts at his law firm with help of his professional team, Fitzgerald has now authored The Bankruptcy Alternative in order to educate a larger demographic. Not only does he give people an insider look on how debt collecting corporations, banks and insurance companies can make it difficult for people to settle their debts, he also shares how to dodge these corporations and end the debt treadmill permanently.
Greg Fitzgerald is available for interviews.
The Bankruptcy Alternative: Keys to Successful Debt Settlement is now available on Amazon.com.
Book Preview: http://www.amazon.com/dp/B07CNXY41T
About Greg Fitzgerald: http://www.amazon.com/Greg-Fitzgerald/e/B07CL9VQ2P
Company Name: Paperback Expert
Contact Person: Michael DeLon
Email: Send Email
Country: United States
Toronto, Canada – Recognized internationally for his research and understanding of embodiment, Philip Shepherd shares how to find true wholeness of being in his new bestseller, Radical Wholeness: The Embodied Present and the Ordinary Grace of Being. According to the author, today’s culture teaches people to live in their heads and habitually seek to outthink every issue that arises. As a result, they have largely sacrificed their ability to feel and live in wholeness or achieve a clarity of being. On an individual basis, though, people can recover their wholeness and gain access to a new, more enlightened way to experience the earth around them – one that reconnects with nature and brings peace and purpose to their work and relationships.
Shepherd describes mankind’s modern way of living as ‘whole-blind’. Although wholeness is the inescapable nature of reality, people have broken their relationship with it by breaking their relationship with the body. Sitting in their heads, they have difficulty feeling the self as a whole or the present as a whole – which means they struggle to feel reality. This throws all their relationships out of balance, a consequence they live with every day. Shepherd describes Radical Wholeness as a call to action. By awakening to wholeness – by once again attuning to the wholeness in which they live – individuals can change their very way of being in the world. And nothing at this point in human history is more desperately needed.
A man of many professions, Philip Shepherd has lived an extraordinary life. At the age of 18, he cycled alone through Europe, Middle East, Iran, India and Japan. He is also an internationally-known actor who has played leading roles in London, New York, Toronto and Chicago, has co-founded an arts magazine, co-created an interdisciplinary theater company, and published his first book, New Self, New World in 2010. Philip has also developed a cutting-edge modality, The Embodied Present Process™ (TEPP), which he teaches around the world, helping people to reconnect their thinking with the intelligence of their bodies in order to experience their true wholeness.
Radical Wholeness is a testament to Shepherd’s unique expertise and offers a path of renewal for humanity. Drawing references from neuroscience, physics, anthropology and a lifetime of experience, the book presents key practices to help readers find the peace, clarity, harmony and presence that come with living in wholeness. Philip Shepherd is available for interviews.
Radical Wholeness: The Embodied Present and the Ordinary Grace of Being is available at any bookseller, including Amazon.com.
About Philip Shepherd: http://philipshepherd.com/about-philip-shepherd
It’s also available as an Audio Book on Amazon, Audible and iTunes.
Backgrounds & Challenges
Overall, the biggest challenging facing SMEs today is a lack of trade finance availability: many traditional financial institutions are unwilling to lend a hand (or a line of credit) to economically disadvantaged SMEs because of the risks associated with lending to small players. This restricts their opportunities for growth and development. Moreover, even where lines of credit are available, there exist substantial needs for credit enhancement options as well.
Cryptocurrencies can help solve these major pain points, but in measured steps.
The global market is slowly beginning to realize the immense benefits that blockchain projects and alternative currencies can bring to the world. Thanks to blockchain technology and the many benefits it brings (such as tamper-proof transactions and impenetrable security, privacy, and transparency), many governments and institutions have slowly changed their stance on cryptocurrencies and we now see more and more large, traditional investors entering the crypto fin-tech space.
Before we actually get there, however, we need to overcome challenges that currently stand in the way of widespread crypto adoption by leveraging the advantages of blockchain technology to deliver solutions that deal with real economic issues. As Brad Garlinghouse, the CEO of Ripple, famously (and very rightly) stated, the value of many crypto projects will fall to zero over the long term; the long-term value of tokens and projects will depend on the utility provided by the project.
With this in mind, the business model proposed by Versara Trade combines the merits of fiat currencies with the advantages of cryptocurrencies to meaningfully and positively impact financial markets. Acting as a credit enhancer to traditional financing, Versara can help millions of individuals and SMEs around the world fund and grow their businesses and take them to the next level. Versara will do this by improving traditional asset-based lending (ABL) and by using cryptocurrency as extra collateral (which is known as “crypto credit enhancement”) as well as by providing blockchain-powered invoices, risk diversification options using proprietary AI algorithms, and by constructing efficient financial models to make trade finance accessible to the retail investor.
By doing these things, Versara promises to deliver viable and effective solutions to credit risk mitigation and access to financial capital. As a result, traditional financial partners have signaled a readiness to work with the technology, and we believe that credit enhancement tools based on cryptocurrency can bridge important gaps where needed, giving the $600 billion emerging SME market better options for growth and expansion.
Two-Level Credit Enhancement
As mentioned above, SMEs are often unable to obtain credit because of the perceived risk to lenders of not getting their money back from high-risk and unverified borrowers. Versara solves this issue by creating two safeguards that will ensure that lender funds are returned, even in the event of default by the borrower.
Pool-specific credit enhancement is the first line of defense against default. An over-collateralized pool of cryptocurrencies is created using funds from crypto-guarantors, and this fund is used to pay fiat lenders in case of default of any loan given out.
Platform-wide credit enhancement is the second line of defense against default. It is similar to pool-specific credit enhancement, but instead of using funds from a pool of crypto assets to pay off lenders in case of default by borrowers, this pool draws from a platform-wide cross-collateral pool, and it is only tapped into if the pool-specific credit enhancement line of defense is depleted of funds.
Onboarding and Underwriting
In order to overcome the second biggest challenge in the face of providing SMEs with loans, which is basically a KYC (Know Your Customer) challenge, Versara users can only be onboarded via referral by other verified users, or by a thorough verification process that verifies invoices based on country, currency, maturity date, and credit profile, along with advanced risk assessment algorithms that screen and filter would-be users before they are able to join the platform.
Platforms and networks of this type can only be effective if they provide tangible benefits to all parties involved in trade. Here are the benefits that various groups can expect to reap by using Versara:
Sellers of goods benefit by having easier access to traditional factoring or asset-based lending while enjoying lower costs as compared to invoice financing.
Buyers of goods are rewarded for simply verifying invoices and other documents, and they enjoy easier access to financing as well as better repayment terms.
Crypto guarantors who provide cryptocurrency to the credit enhancement pool benefit by being able to easily participate in a huge trade finance market, while also gaining access to a new breed of high-yield investment products.
Fiat lenders enjoy diversified credit risk tools, access to an asset-based lending market with additional credit collateral, and lower risks of total default.
The idea for Versara was conceived in October 2017. After putting together the right team for the job, angel investment to fund the project was obtained in early 2018. That was followed by the release of the project whitepaper and completion of legal formalities in Q2 2018.
After a beta prototype of the Versara platform was launched in May 2018, a public token sale (ICO) was held in July, followed by additional improvements and to the platform. The platform is being prepped for formal launch in the US in Q1 2019, launch in selected Asian countries in Q2 2019, and launch in selected European countries in Q3 2019.
Sean Liu, our Founder and CEO, is a seasoned manager with more than a decade of experience in financial products. His areas of expertise include security finance, credit derivatives, and other fixed-income instruments.
Dennis Thankachan, our Co-founder and COO, is an experienced investor in technology and telecommunications projects. Prior to Versara, Dennis was a research analyst at both PointState Capital and Och-Ziff Capital Management and worked on equities in the technology, media, and telecommunications sectors.
Daniel Napierski, our Co-founder and CTO, has years of experience providing professional consulting services to clients ranging from startups to global corporations. Through his consulting practice, he has applied his experience to assist companies in adopting agile methodologies and in rapidly producing prototypes that perform.
By leveraging cryptocurrencies in the trade finance industry, Versara promises to help small businesses flourish while giving investors a unique opportunity to grow their wealth. The platform will provide low operating costs thanks to blockchain technology and proprietary algorithm-based underwriting, the use of cryptocurrency as collateral, risk diversification through the aggregation of invoices into structured asset pools, easier access to effective trade financing tools, and through lines of defense against defaults.
Everyone in the ecosystem, from sellers and buyers to lenders and guarantors, all stand to benefit from the system, either in the form of better access to credit, lower costs of operation, or through the use of highly effective trade algorithms and rewards from simply participating on the platform and vetting and onboarding verified users.
New publications follow the recent exclusive license to Oxitope of an OxPL diagnostic and therapeutic portfolio from the University of California San Diego.
SAN DIEGO – June 7, 2018 – Oxitope, Inc. (“Oxitope”), a privately-held biotechnology company creating diagnostics and therapeutics to treat diseases caused by maladaptive inflammation, today announced the publication of new research in the journal Nature. This publication reports that transgenic mice expressing an antibody fragment of the OxPL-targeting natural antibody E06 exhibited a decrease in systemic inflammation, atherosclerosis, aortic valve calcification, and non-alcoholic steatohepatitis (NASH) along with improved longevity over 15 months, despite extremely elevated low-density lipoprotein cholesterol (LDL-C) levels. The results demonstrate LDL-C independent effects of OxPL on these diseases, which are all age-associated inflammatory conditions that are among today’s leading causes of human morbidity and mortality.
“There has been evidence in the scientific literature, including in vitro, cell culture and epidemiology studies, showing that high levels of OxPL are associated with both acute and chronic diseases caused by maladaptive inflammatory responses. However, an in vivo demonstration of the amelioration of such effects, has not been shown until the current study,” said Joseph L. Witztum, MD, senior author and Professor of Medicine at the University of California San Diego. “This publication, and the work it embodies, represents decades of research originally initiated to elucidate the atherogenic properties of modified LDL-C and has led to a new understanding of the pathophysiological role of oxidative modifications, such as OxPL, in a variety of inflammatory disorders. It is gratifying to now see this research moving out of the laboratory and into translational activities to create diagnostic and therapeutic solutions with the potential to benefit patients.”
The study was conducted by researchers from the University of California San Diego and collaborators at Taipei Medical University; University of Eastern Finland; La Jolla Institute for Allergy and Immunology; UT Southwestern Medical Center; and the Medical University of Vienna, Center for Molecular Medicine of the Austrian Academy of Sciences. The research reported in this publication includes intellectual property invented by Drs. Witztum, Tsimikas and Que, which was part of a recent exclusive, world-wide diagnostic and therapeutic license to Oxitope of a portfolio of OxPL related intellectual property from the UC San Diego.
“These observations, combined with our license, create near and long-term opportunities to translate the findings to improve the care of patients with oxidative/inflammatory disorders which are integrally associated with chronic diseases and complications of aging,” said Alexander Martinez, President and Co-founder of Oxitope. “We are excited by the potential to create therapeutics to intervene at the intersection of accumulated damage from oxidative stress and immune system activation in order to address the highly prevalent, debilitating and often fatal inflammatory diseases people suffer from today.”
Key findings of the research published in Nature:
· OxPL are pro-inflammatory and contribute to the progression of atherosclerosis, aortic valve calcification and non-alcoholic steatohepatitis in control mice.
· Compared to control mice, the mice expressing the OxPL targeting antibody had 28-57% less atherosclerosis, even after one year despite continuous plasma cholesterol levels > 800 mg/dL.
· Mice expressing the OxPL targeting antibody had decreased aortic valve calcification (hardening and narrowing of the aortic valve leaflets), hepatic steatosis (fatty liver disease) and liver inflammation.
· Mice expressing the OxPL targeting antibody also had 32% less serum amyloid A, a marker of systemic inflammation, as well as reduced expression of inflammatory genes by macrophages.
· These effects contributed to the observation that targeting OxPL also prolonged the lifespan of the mice — after 15 months, 100% of the mice expressing the OxPL targeting antibody were alive, compared to 54% of the control mice.
Additional pre-clinical research using the same mouse model expressing the OxPL targeting antibody was also published today in Nature Communications, where, together with colleagues at the University of Arkansas for Medical Sciences, the authors have demonstrated that inflammatory high-fat diets induce bone loss in control mice. These effects were significantly attenuated in the mice expressing the OxPL targeting antibody due to an anabolic effect on bone formation. These findings indicate that OxPL chronically exert a restraining effect on bone formation and that age-related bone loss might be due in part to diminished ability to defend against accumulating oxidative damage, such as OxPL. Optimized versions of natural human anti-OxPL antibodies therefore, may represent a novel therapeutic approach to the prevention and treatment of osteoporosis.
Finally, in a third publication in Cardiovascular Research comparing control mice to the same mouse model expressing the OxPL targeting antibody, it was demonstrated that OxPL are generated within cardiomyocytes during ischemia-reperfusion injury, which often occurs during heart attack or procedures to open occluded arteries, and that such OxPL have detrimental effects on cardiomyocyte viability. Inactivation of OxPL in vivo resulted in a reduction of myocardial infarct size. These observations suggest opportunities for novel therapeutic options in patients suffering from myocardial infarction to preserve heart muscle function and improve long-term prognosis.
“In addition to this compelling preclinical research, our biomarker laboratory at the University of California San Diego has demonstrated in over 50 publications in humans, including prospective studies of up to 15 years, that elevated levels of OxPL measured on lipoproteins in plasma predict the development of a variety of phenotypes in cardiovascular disease and aortic stenosis,” said Sotirios (Sam) Tsimikas, MD, Professor of Medicine and Director of Vascular Medicine at the University of California San Diego, and also a co-author on the three publications. “Additionally, decreased levels of such plasma antibodies binding oxidation-specific epitopes (OSE), such as OxPL and related antigens, are associated with higher risk of cardiovascular disease. All of this work taken together supports both the diagnostic rationale for measuring the target, OxPL, to diagnose and risk stratify patients, as well as the therapeutic rationale for the development of optimized versions of evolutionary-selected and conserved natural human antibodies to OSE to treat a variety of inflammatory diseases with high unmet need despite available treatments.”
About Maladaptive Inflammation, OxPL and OxPL Targeting Medicines:
Inflammation is a protective (adaptive) response to noxious stimuli, chiefly infection or injury, intended for acute activation to restore an individual to a normal functional state. Inflammation is a high-benefit, potentially life-saving response, however, it comes at high-cost due to its ability to override normal function and cause tissue damage or even death. When inflammation is excessive or becomes chronically activated it becomes harmful (maladaptive).
The dramatic environmental changes brought about by modern human populations, including reduced microbial exposure, western diet, industrial toxins, and decreased physical activity have resulted in a population-wide burden of oxidative damage capable of sterile (in the absence of infection) activation of maladaptive inflammation. It has become widely-recognized that this maladaptive sterile inflammation is a key driver of unhealthy aging and today’s primary sources of morbidity and mortality: cardiovascular disease, cancer, obesity, metabolic disease, osteoporosis, arthritis, fatty liver disease, and neurodegeneration.
The maladaptive sterile inflammatory response can be perpetuated or in some cases initiated by OxPL. Some phospholipids, such as the molecules that make up cell membranes, or are present on lipoproteins or on apoptotic cells, are prone to modification by reactive oxygen species (ROS, also known as “free radicals”), forming OxPL. This event is particularly common in inflammatory conditions where cells in the immune system generate ROS as an antimicrobial defense mechanism, leading to generation of OxPL, which then further amplifies the inflammatory response, often noted as activation of inflammatory cells and their genes to generate inflammatory cytokines, such as interleukins. OxPL can also be primarily generated when an individual is exposed to excessive, chronic oxidative stress, the imbalance between ROS and the body’s own ability to detoxify (such as through antioxidant mechanisms) or repair oxidative damage, resulting in the recognition of OxPL by the immune system and initiation of an inflammatory response.
Existing and emerging anti-inflammatory therapeutics generally target a single, downstream molecular component of an already activated inflammatory response, relying on immunosuppression to achieve a therapeutic effect. This immunosuppression limits use in broad, preventative indications and vulnerable populations. OxPL-targeting therapies, because they are not targeting components of the immune system and are generally upstream of cytokine release, have the potential to impact proximal immune system activity in a manner that attenuates multiple inflammatory pathways. Importantly, this occurs without the immunosuppressive effects of current therapies.
Oxitope’s goal is to enable people to live long and healthy lives by preventing, halting or reversing acute and chronic diseases driven by maladaptive inflammation, which today result in progressive disability and death. To that end, Oxitope is focused on developing diagnostic and therapeutic modalities that target oxidation-specific epitopes (OSE), such as OxPL. OSE are highly pro-inflammatory and play a central role in the oxidation/inflammatory contribution of many chronic diseases. Oxitope’s initial diagnostic focus is transferring its OxPL-based diagnostic tests for use in the clinical setting where measuring OxPL has predictive value, including reclassifying up to 30% of patients with cardiovascular disease, independent of traditional risk factors. Oxitope’s initial therapeutic focus is creating medicines that selectively target OxPL in rare diseases with high unmet medical need that also serve as unique opportunities to explore the biology of targeting OxPL in broader diseases of maladaptive inflammation and aging, such as non-alcoholic steatohepatitis, arthritis, atherosclerosis, aortic stenosis, ischemia-reperfusion injury, osteoporosis, pain, and autoimmune diseases.
The company can be contacted for more information at www.oxitope.com.
Shenzhen Yida Acrylic Product Manufacture Co., Ltd, the China-based manufacturing company with many years of experience, introduces a new set of acrylic materials at affordable costs to provide global retailers with more effective means of advertising products while ensuring that packaging industries provide better finishing for goods. The Yida acrylic products include Acrylic box Case, Acrylic Crafts, Glass Displays, Calendar Stands, Acrylic Photo Frames and more.
Recently, there is an increased demand for acrylic products for various applications due to its better quality. Among several applications, their use in packaging, display and signage is, so far, estimated to be the largest application segment in today’s global market. The acrylic sheets have been considered a cost-effective substitute for the conventional polycarbonate materials used in signage and display applications.
The cast acrylic display products are expected to boost global market as they are used in retailers’ point of purchase to increase product credibility, brand awareness, and sales. They will also cause a drastic reduction in the high cost incurred during product advertisement, hence significantly increasing the retail industry.
Shenzhen Yida Acrylic Product Manufacture Co., Ltd, as one of the major companies operating in the acrylic products market, is continually investing to increase their product portfolios, coupled with improvements in the distribution to global customers. The company has adopted several strategies such as new product developments and expansions to take care of the increasing demand for cast acrylic sheets from several countries.
Now, they have made available a new set of acrylic boxes for packaging industries to replace the extensively used wood, metal, and glass materials for finished goods. These boxes come in wide variety of designs, colors, and shapes and are used in packaging jewelry piece, readymade clothes, a bundle of books and more. Other applications can be seen in the acrylic photo frames which are designed for the valuable pictures, such as a postcard, Amazon prints, currency, tickets, greeting cards, baby pictures, awards and more.
Clients who are interested in knowing more about Shenzhen Yida Acrylic Product Manufacture Co., Ltd, their Products, and other services are urged to visit their website on www.yidaacrylic.com
About Shenzhen Yida Acrylic Product Manufacture Co., Ltd
As one of the largest professional factories in China, Shenzhen Yida Acrylic Product Manufacture Co., Ltd specializes in the manufacture of acrylic products and acrylic displays. The company has over 200 technical personnel an expert management team who possess more than 10 years of work experience in addition to a set of advanced production equipment.
Company Name: Shenzhen Yida Acrylic Product Manufacture Co., Ltd
Contact Person: Jason Chan
Email: Send Email